Frankie wears a stylized Powerpuff Girls shirt.
This is the first Cartoon Network Studios show done in Macromedia Flash, enabling a small staff to produce an entire episode in-house.
In Bloooo (2004), where Bloo becomes ill and turns white, Wilt, Eduardo, and Coco think of ways to capture the ghost while mentioning several movie titles pertaining to ghosts. (Coco says 'Co coco!' as the song 'Ghostbusters!' goes, and Wilt talks about the Star Wars: Episode I - Die dunkle Bedrohung (1999).)
The character Mr. Herriman is loosely based on Peter Cushing's portrayal as Dr. Abner Perry in Der sechste Kontinent (1976).