Kiba means "Fang". Tsume means "Claw". Hige means "Whiskers". Toboe means "Howling".
In Episode 11, "Vanishing Point", Julius from Cowboy Bebop makes an appearance.
When recording his lines for Kiba in the opening scene, Japanese voice actor Mamoru Miyano was extremely nervous and had trouble recording his lines, even freezing up completely before calming down and completing the scene.
In the first episode, when one of the auto-defense mecha is disabled, the sound it makes is that of the Millennium Falcon's hyperdrive failing to work from Star Wars: Episode V - The Empire Strikes Back (1980).
All of the main character wolves have names that, in Japanese, refer to a part of a wolf. For example, Toboe's name means "howling".