Emily VanCamp and Chris Pratt became romantically involved while playing sister and brother Amy and Bright Abbott.
Treat Williams was the only actor to appear in every episode of the series. Gregory Smith was absent only from the season three finale and Emily VanCamp's only absence was from the episode The Land of Confusion (2006).
Nancy Everhard who plays Colin's mother in the show and Tom Amandes who plays DR Harold Abbott are married in real life since 1996
Gregory Smith and Emily Vancamp revived their characters Ephram Brown and Amy Abbott in the zoom reading of 'crisis on infinite teen dramas' in 2020. They are the only cast members to read for their original characters.
In the episode Daddy's Little Girl, the WB originally planned to air it without bleeping the word "shit". However, this decision was changed sometime over the weekend before the episode aired.