Griswold the Blacksmith, Wirt the peg-legged boy and Deckard Cain are the only characters from the first Diablo to be seen in this game. However the classes from the first game appear as villains; The warrior appears as the Dark Wanderer, the rouge is Blood Raven, and the Summoner appears as a corrupted version of himself.
The rogue mercenaries have the same appearance as the original rogue hero in the first Diablo.
Several unique items from the game are re-used from the first Diablo, such as Veil of Steel, Harlequin Crest and Arkaine's Valor.
Rebecca Lowman's debut.