One of the show's writers used to hang out on a BBS forum for Fox shows when this was still on the air. He said that if the show had survived into a fourth season, there was going to be a second set of head characters introduced, this time for the "Heddy" character.
There are several jokes referring to Louise sounding like that girl from Die Simpsons (1989). Yeardley Smith is the voice of Lisa Simpson.
The first season's opening segment featured a voiceover which set up the show's premise. The voiceover was done by veteran character actor Dave Madden.
FOX aired its first condom commercial during this show in 1991. It was the first condom commercial to air nationwide, and is often mistakenly thought to be the first condom commercial ever broadcast. California station KNTV aired the first condom commercial in 1975.