The drug lord mansion destroyed by the missile was a real brick-and-mortar residence in Mexico purchased by the filmmakers from a divorcée who had unpleasant memories of the place. The filmmakers bought the mansion and destroyed it. The divorcée kept the land and presumably built a new house after clearing out the rubble.
The assault on the SUVs was filmed in Mexico to recreate what the filmmakers believed looked like a Bogota street. Harrison Ford did his own stunt driving in the final escape.
In Tom Clancy's novel, Ryan breaks into Ritter's safe to obtain the damning documents. The filmmakers thought that was too clichéd for film and created the dueling computers scene instead.
The scene in which the convoy of Suburbans is attacked by the drug cartel is now used as a training video in U.S. government agencies. The footage was also used in an episode of J.A.G. - Im Auftrag der Ehre (1995).
Ryan's line asking Ritter if he played tennis (to distract him during the computer showdown) was ad-libbed by Harrison Ford.