During the making of the series, Vanessa Angel (Lisa) was introduced to her husband Rick Otto by Lee Tergesen (Chett Donnelly).
In the first episode, Gary says that creating Lisa is possible because he saw it in a John Hughes movie once. The movie of course is L.I.S.A. - Der helle Wahnsinn (1985), which spun off the series.
Kelly LeBrock, who played Lisa in the 1985 movie, was asked to play Lisa again in this TV adaption, but turned the role down.
In the episode "Quantum Wyatt", Wyatt Quantum Leaps into different people's bodies. When he looks in the mirror, he sees the body of the person he leaped into. The is an obvious reference to the hit TV show, Zurück in die Vergangenheit (1989). Michael Manasseri, who plays Wyatt Donnelly, once guest starred in an episode of Quantum Leap - 'Return of the Evil Leaper'