In the first show of the 1992-3 season, Garfield says at the end of the opening theme, "And don't bother checking what's on National Broadcasting Company (NBC). They're not running cartoons anymore." In 1992, NBC really stopped broadcasting Saturday morning cartoons.
Creator Jim Davis originally wanted to make a series based on his comic strip "U.S. Acres". But CBS insisted that "Garfield" be made the star of the series with the "U.S. Acres" characters becoming the "Friends" of the title.
The show had four completely different opening sequences and three theme songs over the course of its run.
The little duck head on Wade's inner tube usually has the same expression on its face as Wade himself.
Lanolin (the name of the female sheep from the "US Acres" cartoons) is also the name of an oily secretion found in the wool of sheep.