The actresses consumed over 100 cheesecakes during the show's seven-year run. Bakeries from around the USA would send in cheesecakes for them. Bea Arthur hated cheesecake in real life.
It was not originally scripted for Blanche to have a Southern accent. Instead, it was Rue McClanahan's idea to introduce it.
When the show first aired, Queen Elizabeth the Queen Mother loved it so much that she wrote to the four actresses and asked them to perform a live show especially for her. They obliged, and acted out a sketch during the The Royal Variety Performance 1988 (1988), at which the Queen Mother was present, in which the girls are depicted onstage visiting London, first interacting with the host Ronnie Corbett and then sitting down for dinner, recreating various moments from previous episodes.
Throughout the series, there are many jokes made by the girls, at Rose's expense, regarding her natural hair color. Betty White was in fact a natural brunette and dyed her hair blonde.
Betty White was the oldest of the four main actresses. With the death of Rue McClanahan, she became the last surviving member of the cast, until her passing on December 31, 2021. White was also the oldest of the eight regulars of Mary Tyler Moore (1970) and, during the last four months of her life, she became the last surviving cast member of the show.