The Pope/Michelangelo sketch was based on a historical incident. The Renaissance artist Paolo Veronese really did paint a "Last Supper" with extraneous contemporary elements. The Inquisition investigated and advised him to remove those elements. Instead, he really did just rename it - to "Feast in the House of Levi".
This marks the last time The Ministry of Silly Walks sketch was performed by the troupe. John Cleese had a hip and knee replacement in 2010, thus making Cleese unable to perform the fan favorite Silly Walks anymore.
The "Custard Pie Lecture" sketch predates Monty Python. It was written by Sir Michael Palin and Terry Jones while they were students at Oxford, and was their first writing collaboration.
Some changes were made to the sketches for this venue. The line in "Nudge, Nudge" about Terry Jones' wife were changed to say she was from "Glendale, California". Obscenities that were forbidden on television were used freely in many cases, and potentially confusing Anglicisms were altered ("dustman" became "garbageman" and so on).
Filmed in September 1980, this is a compilation of five shows. HBO filmed all of the shows and intended to release the full two-hour show, using the best versions of each sketch. Amongst the items missing are Terry Gilliam's "A Christmas Card" animation and Neil Innes performing "Stoop Solo" backed by Carol Cleveland as a three-headed back-up singer.