The names Ruff and Reddy come from U.S. president Zachary Taylor who was nicknamed "Old Rough and Ready".
This was the first television show produced by Hanna-Barbera.
Virtually all the voices on the show were supplied by Daws Butler and Don Messick. This is because at the time voice actors were paid by the recording session, regardless of how many voices they did during the session. This is also why female characters hardly ever featured on the show.
First H-B cartoon to be premiered on a prime-time channel.
First Hanna-Barbera cartoon premiered for a broadcast channel. Also, this is the first cartoon to be premiered on NBC.