The postwar era saw all things Italian become hugely popular in the U. S. Cuisine, cinema, fashion and music all showed the influence of Italy on them, and that included cartoons such as this one.
The score for this cartoon was featured (in Stereo) on the audio CD "Tom & Jerry & Tex Avery Too!".
The American GI presence in WW2 Italy meant that things like Hershey's chocolate bars, bubble gum, and cartoons were introduced to the population, to popular acclaim. The fact that the little Neapolitan mouse recognizes the famous duo would indicate this.
Before producing the long-running "Tom & Jerry" cartoon series, codirected by William Hanna and Joseph Barbera, longtime MGM producer Fred Quimby had won only one Oscar for best cartoon, for Die Milchstraße (1940), directed by Hugh Harman.
The lush background artwork of the Bay of Naples, Mt. Vesuvius and the town environs are accurate representations of the area at the time.