Although they share no scenes, William Powell and Asta appear in this picture, more than a year before Mordsache Dünner Mann (1934) series began.
The miniature buildings Vance uses to illustrate his theory are the actual miniatures used earlier in the picture.
All the dialog and plot elements involving the two murdered men, including their names, were used again seven years later in Calling Philo Vance (1939), in which James Stephenson plays Philo Vance. In both movies, the dialog in the scenes pertaining to the murders and the investigation is exactly the same, which indicates that the script from this film was adapted to the story for the latter film, which focuses on the theft of secret aircraft plans. However, in this film, the plot pertains to stolen Chinese art objects.
Dr. Doremus' repeated line "I'm a doctor not a . . . " was later used as the catchphrase of DeForest Kelley's character Dr. Leonard "Bones" McCoy on Raumschiff Enterprise (1966).