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When twins Holly and Dylan Meredith go missing, Family Liaison Officer Lisa Armstrong realises her connection to the family might be more than just professional.

With the Meredith family reeling from Dylan's death and Sean's arrest, Lisa is charged with investigating Sean's alibi and makes a game-changing discovery.

Nick Mooney has gone missing, Holly's backpack has been found, and Lisa's children both get into trouble.

With Nick seriously injured in the hospital, Lisa furiously seeks out Sean, while Med feels increasingly sidelined. Sean's revelations lead the team to suspect Nick might have vital information about Holly and Dylan, and they desperately wait for him to regain consciousness. Meanwhile, Rob attempts to leave the online forum, but finds it is not as easy as he had hoped, and Sam tries to offer Abbie a way out from Vincent.

A confession to Lisa shines a new light on Dylan's killer, Abbie has a terrifying experience with some local junkies while Med begins his own investigations.

Despite what Holly tells the police that she killed her brother, they believe there's is more to the truth than she has told them.