Originally they were going to be rabbits, but the executive said to make them human so they can be relatable. Chris Savino agreed and liked the idea. He said in an interview that if he didn't follow the recommendation, this show would not exist.
His siblings are bossy eldest child Lori, ditzy, yet beautiful Leni, aspiring rock star Luna, aspiring comedian Luan, athletic Lynn, gloomy goth Lucy, polar-opposite twins tomboy Lana and girly Lola, child prodigy Lisa, and baby Lily.
This is one of the few Nickelodeon series to actually show blood. Others include Ren & Stimpy and Rocko's Modern Life.
Clyde has two dads named Howard and Harold, making them the first gay interracial family to appear on a Nickelodeon show.