All of the titles in the first season have one word. All of the titles in the second season have two words. And all the titles in the third season have three words. Likewise with seasons 4 through 9.
Shares a universe with other shows created by Dick Wolf: Law & Order: Special Victims Unit (1999), Chicago Fire (2012), Chicago P.D. (2014) and Chicago Justice (2017). This means that sometimes characters of Chicago Med appear on his other shows and its story continues there or vice versa. One of main characters of this show is Dr. Will Halstead, who was introduced before the backdoor pilot (in Say Her Real Name (2015), as the brother of Chicago P.D.'s Jay Halstead.
Laurie Holden appeared in the backdoor pilot (I Am the Apocalypse (2015)) in April 2015 as Dr. Hannah Tramble and was set to star in the series, but in August 2015, she announced that she will not appear in the series. The producers said that her role will not be recast, but they will add new female roles (an emergency pediatrician, a charge nurse and a young first-year resident), before the filming begins in September.
Dr. Natalie Manning's name was originally Lilly before the show aired, as clearly seen on her lab coat in early promotional pictures, but was changed before the pilot episode.