Joanne Siegel wurde am 1 Dezember 1917 in Cleveland, Ohio, USA geboren. Sie war mit Jerry Siegel verheiratet. Sie starb am 12 Februar 2011 in Santa Monica, California, USA.
She was hired as a model by Joe Shuster, the comic-book artist who, along with writer Jerry Siegel, was developing the character of Superman. The facial features and hairstyle of Lois Lane were based on her.