- His Star Trek character "Q" was named for British fan Janet Quarton and close friend of the late Gene Roddenberry.
- Formed "Alien Voices" in 1996 with Leonard Nimoy and writer-producer Nat Segaloff. "AV" does audio remakes of classic science fiction and fantasy stories...including "The Time Machine" and "The Lost World", among others.
- He was both the first and last credited guest star seen in Raumschiff Enterprise: Das nächste Jahrhundert (1987).
- In a 2012 interview, John de Lancie recalled his original audition for the role of Q, after which the show's legendary creator Gene Roddenberry approached him, touched him on the shoulder, and said, 'You make my writing sound better than it is'.
- Good friends with fellow "Star Trek" alumna Kate Mulgrew.
- Was the first actor to ever use the word "trek" on "Star Trek" (in the Raumschiff Enterprise: Das nächste Jahrhundert (1987) series finale "All Good Things..."). However, James Cromwell is the only actor to utter the words "star trek" in the franchise (in Star Trek - Der erste Kontakt (1996)).
- In seven seasons, he made eight appearances on Raumschiff Enterprise: Das nächste Jahrhundert (1987).
- Good friends with Macgyver (1985) and Stargate: Kommando SG-1 (1997) star Richard Dean Anderson. They have appeared in episodes of both those series and as well as Legend (1995) together.
- In 1987, John DeLancie, perhaps unwittingly, carried on an interesting tradition. In the 1960s, the original Star Trek and original Mission: Impossible frequently used the same cast of character actors as guest stars since both were creations of Desilu Studios. When both Mission: Impossible and Star Trek were relaunched, DeLancie played the villain for both pilots.
- Along with Jonathan Frakes, Marina Sirtis, Armin Shimerman, Michael Ansara, Richard Poe and Mark Allen Shepherd, he is one of only seven actors to play the same character on three different live-action "Star Trek" series. He played Q on Raumschiff Enterprise: Das nächste Jahrhundert (1987), Star Trek: Deep Space Nine (1993) and Star Trek: Raumschiff Voyager (1995).
- In addition to his acting career, he hosts the children's series of the Los Angeles Philharmonic (2005).
- He helped create and co-hosts "Star Trek: The Music", a concert presentation with narration, with the Toronto Symphony. His co-host is fellow actor Robert Picardo, who portrayed the Doctor on Star Trek: Raumschiff Voyager (1995). (Juni 2008)
- He is best known by the public (and by many sci-fi fans) for his role as the iconic being Q on Raumschiff Enterprise: Das nächste Jahrhundert (1987), Star Trek: Deep Space Nine (1993) and Star Trek: Raumschiff Voyager (1995).
- Along with Marc Alaimo, Rosalind Chao, Jeffrey Combs, Michael Dorn,Jonathan Frakes and Tim Russ, he is one of only six actors to appear in ten different seasons of "Star Trek": Raumschiff Enterprise: Das nächste Jahrhundert (1987) Seasons One through Four, Six and Seven, Star Trek: Deep Space Nine (1993) Season One and Star Trek: Raumschiff Voyager (1995) Seasons Two, Three and Seven.
- Played Eugene Bradford on "Days of Our Lives" for 520 episodes between 1982-1990. While on the show, his character fell in love with Calliope Jones, played by the late Arleen Sorkin.
- The first prevision of his role as Q was when he appeared in Little Women Part I (1978) with William Shatner, who played Captain James T. Kirk on the original Raumschiff Enterprise (1966) series and subsequent movies.
- Son of Andrea and John Sherwood Keegan de Lancie Sr.; the latter was principal oboist of the Philadelphia Orchestra from 1954 to 1977.
- Is one of only 26 actors that have acted in both the Doctor Who and Star Trek franchises. He also played a doctor in 3 episodes of Notruf California (1972) and in Die Hand an der Wiege (1992). He helped create and co-hosts "Star Trek: The Music", a concert presentation with narration, with the Toronto Symphony. His co-host is fellow actor Robert Picardo, who portrayed the Doctor on Star Trek: Raumschiff Voyager (1995).
- Father of Keegan de Lancie and Owen de Lancie
- Was a celebrity spokesman for Compaq computers. His son Keegan de Lancie (full birth name: John Sherwood Keegan de Lancie III), appears in commercials for Dell computers.
- Grew up in Philadelphia, Pennsylvania, the same city as Star Trek: Raumschiff Voyager (1995) star Robert Picardo.
- One of his first Star Trek conventions after playing the role of "Q" was with George Takei at "Starbase 21" in Tulsa, Oklahoma in 1987.
- After appearing in two airline disaster themed films, Death Flight (for TV) and Fearless (opposite Jeff Bridges), he would famously play a troubled air traffic controller on Breaking Bad (as Jane's grieving father).
- Speaks French fluently.
- There is a character named John DeLancy in Mr. Monk Stays in Bed (2005).
- Character actor of immense talent that is facially confused by attendees with John Larroquette, as being [tbc] a public attendee of the most densely packed (UK non-Award), celebrity event 'Save the Rose Theatre' campaigns, public PR day, May 1989.
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