- Like many tourists, Cartwright attempted to disturb the notoriously unflappable guards at Buckingham Palace in London. When she blurted, "What's happening man, I'm Bart Simpson, dude!", she succeeded.
- For her birthday, a 1992 episode of "The Simpsons" featured its opening of Bart writing as punishment on the chalkboard, "I am *not* a 35-year-old woman.".
- Was offered the chance to do the female voices for South Park (1997), but turned it down because she felt the show was too offensive.
- When she auditioned for Die Simpsons (1989), she was originally called in for the voice of "Lisa Simpson", not "Bart Simpson". She was then asked to read for "Bart Simpson" and got the role on the spot.
- She met the future Supervising Director of Die Simpsons (1989), David Silverman, when they were both students in UCLA's Art Department in the late 1970s. They jokingly made an agreement they would one day work on a show together, but didn't find out their deal came through until they saw the credits of the first episode of the series.
- The segment of Unheimliche Schattenlichter (1983) in which she appears is based on the same episode that was later parodied in a "Simpsons" Halloween special.
- Aunt of Sabrina Carpenter and Sarah Carpenter. She is their father's step-sister.
- Her character, Bart Simpson, was rated number 2 in Comedy Central's newest show 'Mouthing Off: 51 Greatest Smartasses'.
- Fittingly her character Ethel in Unheimliche Schattenlichter (1983), years before her role as Bart Simpson, is "wished" into a television set where she is chased around and then eaten alive by a cartoon monster.
- Was friends with Daws Butler, the voice of Yogi Bear, Huckleberry Hound and hundreds of others. They regularly exchanged letters, and soon he was addressing her "Dear Pixie." He sent her scripts to record, and then critiqued the tapes she returned. At 12, she joined a children's theatre company and made her first stage debut in "An Old-Fashioned Christmas". The director asked her to join his summer theatre group. She traveled with them for four years. As a senior, she was president of the Forensic League at Fairmont West High school.
- Attended Ohio University from 1976-1978 as an interpersonal communication major and was awarded the Cutler Scholarship for academic excellence and leadership.
- Originally auditioned for the part of Lisa Simpson on The Simpsons (1989) but asked to read for Bart because she thought Bart was funnier.
- She has appeared in two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Falsches Spiel mit Roger Rabbit (1988) and Arielle, die Meerjungfrau (1989).
- Appointed Honorary Mayor of Northridge, California, USA (2005)
- Children, with Warren Murphy, Lucy Mae and Jackson.
- She is a lifelong Democrat.
- Became a Scientologist in 1991.
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