- Her Boston accent in Gone Baby Gone - Kein Kinderspiel (2007) was so convincing that Ben Affleck, a Boston native, asked what part of the city she was from, and a security guard once initially refused to let her on set as he believed that she was a local fan.
- Director Sidney Lumet was so impressed with her ability that he cast her in three different roles -- Ellen, Paris and Rebecca -- in his television series 100 Centre Street (2001).
- Was nominated for Broadway's 2005 Tony Award as Best Actress (Featured Role - Play) for a revival of "A Streetcar Named Desire."
- Ryan, her professional surname, is her mother's maiden name.
- Best friends with Patricia Clarkson.
- Gave birth to her 1st child at age 41, a daughter Georgia Gracie Slovin on October 15, 2009. Child's father is her fiance [now husband], Eric Slovin.
- Graduated from New York City's High School of Performing Arts.
- Was nominated for Broadway's 2000 Tony Award as Best Actress (Featured Role - Play) for a revival of "Uncle Vanya."
- As of 2016, has appeared in 3 films that were nominated for the Best Picture Oscar: Capote (2005), Birdman oder (Die unverhoffte Macht der Ahnungslosigkeit) (2014) and Bridge of Spies - Der Unterhändler (2015). Of those, Birdman is a winner in the category.
- She is of English, Irish, and Polish descent.
- Appeared with Philip Seymour Hoffman in 3 films: Capote (2005), Tödliche Entscheidung (2007) and Jack in Love (2010).
- Was 3 months pregnant with her daughter Georgia when she completed filming Jack in Love (2010).
- Returned to work 5 months after giving birth to her daughter Georgia to begin filming Win Win (2011).
- Her first film role was in Allison Anders' 1996 film Grace of My Heart (1996), although her scene was later cut. She played the second wife of Eric Stoltz's character, in a scene where he picks up his daughter from first wife Illeana Douglas' apartment.
- Attended Stagedoor Manor Performing Arts Training Center.
- First appeared on Broadway in "The Sisters Rosensweig".
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