- Is probably best known for playing deranged and morally degenerate characters both in movies and on television, e.g. in Der Knochenjäger (1999), Alien - Die Wiedergeburt (1997) or the organic-hating hologram in the Star Trek: Raumschiff Voyager (1995) episode Revulsion (1997). Among other psychotic roles, also played the deranged blood bank technician from the Star Trek: Enterprise (2001) episode Carpenter Street (2003).
- The two killers from the beginning of A History of Violence (2005) (who meet their end in the café) are named Leland Jones and William Orser as an inside joke by David Cronenberg, who acted with Orser in Resurrection - Die Auferstehung (1999).
- Eloped and married his first wife, Roma Downey, in a Roman Catholic ceremony in Rome, Italy.
- Attended Cathedral School for Boys in San Francisco.
- Son, August Tripplehorn Orser, born at Cedars-Sinai Medical Center (Los Angeles), 7 pounds, 8 ounces. (23. Mai 2002)
- Son-in-law of Tom Tripplehorn.
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