- Younger brother of Jerry O'Connell.
- Foil fencer while attending New York University. Competed in 1996 NCAA Championships. For two years, Charlie was captain of NYU's fencing team.
- Starred as Colin Mallory in Season 4 of the science fiction television series Sliders - Das Tor in eine fremde Dimension (1995). His character was the brother of Quinn Mallory, portrayed by Charlie's real life brother Jerry O'Connell.
- Brother-in-law of Rebecca Romijn.
- Formerly roommates with his brother Jerry O'Connell.
- Dolly O'Connell & Charlie O'Connell's uncle.
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