- O'Brien's father was the late actor Edmond O'Brien, and her mother is entertainer Olga San Juan.
- She was awarded the 1990 Drama Logue Award for Outstanding Performance for "The Maids" at the Mark Taper Forum Theatre in Los Angeles, California.
- Second wife of Michael Anderson Jr..
- Niece of Liam O'Brien.
- Sister of Brendan O'Brien and Bridget O'Brien Adelman.
- Sister-in-law of Ingrid K. Behrens and Barry Adelman.
- Ex-daughter-in-law of Michael Anderson.
- Ex-sister-in-law of David C. Anderson.
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