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In this Flemish detective series, serious crimes are investigated, usually leading to arrests by the sullen, socially inept detective Tom Segers and his female partner. Together with their police quad, they fight crime from the center to the port of Antwerp. Under the uniform of each character we find a real human of flesh and blood, with his or her love, hope and expectations, but also with many problems and disappointments.

Years ago, a late nurse's young daughter, Ella, was discredited with stepfather Norbert by his wicked daughter Clio and send off to and exploited by her aunt 'tarantula', her only comfort being the friendship of young Jens. Once 18, Ella leaves and ends up in Lier, where Dr. Norbert is running a private clinic owned by recluse Nicolas De Prins's family. Intrigues abound long before Ella meets and recognizes either relative, her mysterious dad or Jens, who ends up comatose after chasing her. Meanwhile Ella made new friends and moved in with a loony hairdresser and her gay deputy Anthony.

A health center run by five specialists offers the arena for the most diverse medical cases. Each episode focuses on the consultations of one or two different patients and the eventual diagnoses.