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A drug-addicted nurse struggles to find a balance between the demands of her frenetic job at a New York City hospital and an array of personal dramas.

In the series premiere, a veteran nurse hides an affair and a drug addiction.

Job stress threatens Jackie's recommitment to family.

Jackie dispenses illegal medical marijuana to a needy patient.

Jackie refuses a friend's loan and is caught snorting drugs.

Jackie is confronted by those who know her secrets.

Coop insults a big donor; Jackie reconsiders her renewed affair.

A family vacation unravels when Jackie leaves her pills behind.

Eddie dates a friend of Coop's; Grace sees a psychiatrist.

Jackie is discovered getting a phony prescription, while Eddie returns to All Saints, and Coop laments the end of his star-making media campaign.

Jackie covers for a hung over O'Hara; Eddie befriends Kevin.

Coop becomes the hospital's face in a public marketing campaign.

Jackie sleeps with Eddie again, then finds a new drug score.

Jackie sets up a secret post office box; Akalitus rehires Eddie.

Jackie's marriage is strained, as is her relationship with O'Hara after the intervention; Akalitus warns the staff that nearby hospitals have closed down, straining the staff and resources; Zoey publicly confesses her affair with Lenny.

Jackie is placed on probation over the Oncology drugs she stole.

O'Hara agrees to help Jackie dose down; Kevin is oddly evasive.

Jackie dodges a urine test; Kevin makes a confession.

Jackie is remorseful when she hears O'Hara is seeking a new job.

Kevin's sister visits; street vendors are injured in a turf war.

Jackie conceals her stash in a new spot; O'Hara becomes ER chief.

Jackie panics when her stash runs low; Coop receives bad news.

The Church removes its chapel statues; a new nurse annoys Jackie.

Kevin finds Jackie's stash so she steals drugs from Oncology.

Jackie accuses Kelly of impropriety with two high school girls.