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Rob Brydon presents a discussion about Little Britain (2003).

When a boat carrying illegal passengers is found crashed in the Thames, the team investigate.

The team follows the trail of the people traffickers, and has to find any remaining survivors before a highly contagious disease breaks.

Harry investigates a case of hit and run where the victim was a 16 year old boy from the nearby housing estate. Working with Sgt. Susan Fenn, they attempt learn if this was an accident or intentional. Harry takes quite a liking to Susan and is shocked by a sudden turn of event. Leo examines a death resulting from a house fire where the lady of the house died. He is puzzled at why she was unable to leave and the police immediately suspect the husband, who was in a nearby park with the children, of murder. Nikki looks into the case of a young woman who collapses at her hen night. She had recently had minor surgery and was taking pain killers, but there is surprising information to be found about her background.

Alison Garland is a 14 year old schoolgirl found dead on the school grounds just after lunch. She appears to have slit her wrists and committed suicide, but there is also evidence that she had sexual relations just earlier that day. As Leo Dalton looks into the case he learns that Alison was also a school bully and was a very unhappy young woman. Harry assists the police in the stabbing death of a car dealer. The evidence suggests that he was stabbed in his garage and his body then dumped. The case takes a radical twist when they find that the knife found by Alison's body was also used to kill the car dealer. Nikki assists the police in the death of an elderly woman who appears to have been maltreated.

A third murder is discovered on school grounds and Leo realises the killings are connected to a sinister teenage pact. Meanwhile, Nikki proves her elderly victim died of hypothermia - but there is still a guilty party to be caught.

Harry and Nikki deal with the case of a young woman who is found dead in an animal shelter. Her dead body has obviously been posed and the autopsy reveals she may have been tortured before death. Information from police intelligence suggests that they may be dealing with a group of radical animal rights activists. It all becomes quite personal for Harry when Nikki is taken prisoner. It's also a difficult time for Leo who has been asked to appear before a medical council hearing and testify on the propriety of a close friend's medical research. Harry has been offered a prestigious chair at an American university, but has had difficulty discussing the issue with his colleagues, especially Nikki.

Harry and the police desperately search for Nikki as they continue to find more bodies. The animal rights activists' target is a well known pharmaceutical firm that is undertaking research on behalf of the government. Leo finally decides on a course of action in testifying at the medical council hearing.

Harry Cunningham is asked to review a case in a insurance dispute. The insurance company is refusing to pay out on an policy when the autopsy results show that the woman was intoxicated and likely was responsible for the fall that killed her. Her family insists that that is impossible as she was an abstainer. Nikki Alexander investigates when human remains are found buried in an field. The locals believe the body to be that of Clara Young, who had disappeared 18 months before. The remains are found on the site of a travelers or gypsy caravan site and the police are convinced that George Wood, one of the camp residents is responsible, but Nikki's evidence proves otherwise.

George Wood is released by the police but he is soon found dead in his caravan. Although made to look like a suicide, it is clearly a murder. The case gets even more complicated for Nikki and the authorities when she determines that there are the remains of two victims in the field, not just one. The evidence in the George Wood murder points to someone with connections to the police. Harry Cunningham believes that the dead woman in his insurance case was likely suffering from dementia and looks to prove the cause

Harry Cunningham investigates when a car accident reveals two bodies inside one coffin. The coffin contained the body of 80-year-old Ethel Mortimer, who was supposed to be there and also that of James Featherton, a high tech sales rep who also had a heavy cocaine habit. Leo Dalton and Nikki Alexander have to deal with the death of a young child who died post-operatively. The pediatric surgeon in the case, Alice Huston, is well known in her field but may be prone to undertaking aggressive surgeries. The pathologists find a connection between the two cases when Featherton's girlfriend is found to be a nurse on Huston's surgical team.

Leo Dalton investigates the death of a young boy whose body is found in the river. He was badly abused and his hands and feet were severed. The child is found to have been HIV positive and the pathologists determine that he may have been the victim of a ritual killing., perhaps as part of an exorcism that went too far. When the skeletal remains of another child are found, Leo believes the police have focused their investigation on the wrong man. Nikki Alexander investigates the apparent suicide of Father Anthony Reid who appears to have jumped from his apartment window on the grounds of a well-known Catholic school. He had colon cancer but those who knew him question that he would take his own life. Harry Cunningham looks into the case of Austin Chambers who is found floating in his swimming pool with an obvious ligature mark on his throat.

When a second person, Vincent Fricks, is found dead with ligature marks around his neck, Nikki and Harry not only find a connection between the two dead men but also with the school where Father Reid committed suicide. They also find another common link between the three. Leo Dalton continues his investigation into a local church that combines Christian with African beliefs and customs. He manages to find physical evidence linking one of the dead boys to the church.

With Claire Kowalski missing and Nikki Alexander unconscious from a blow to the head, Harry and Leo investigate exactly what is going on at the hospital. Harry discovers that a member of Huston's surgical team is not who they claim to be and has actually stolen the identity of someone who died six years before. Blackmail is at the center of it all and it turns out Alice Huston is hiding a secret. However, the killer is identified only by looking to old friendships and the calling in of an old debt.

Nikki Alexander begins to have serious doubts about her conclusions four years previously when her testimony helped acquit 17-year-old Anna Holland of murder. Anna's mother had withheld information from the police and as Nikki reconstructs the scene of the crime, she realizes that the blood spatter evidence no longer holds up. The police focus on the dead woman's husband but the pathologists find that a series of unsolved murders may have a bearing on the case. Nikki is also annoyed with her father, who has conned Harry Cunningham into completing a second autopsy on his late wife.