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Un compuesto de tres episodios reeditados de la serie de televisión de 1952, Gangbusters, estrenados en los cines en 1957 como largometraje. Gang Busters (1954) fue un esfuerzo similar.

Se dramatizan historias de crímenes reales y sus investigaciones.

In the town of Pompeii, 79 A.D., a few weeks before the volcanic eruption of Vesuvius, a Roman lady Hélène meets and falls in love with a young Greek man Lysias. He is betrothed to another woman who, to win him back, acquires a potion to make him love only her. The potion was prepared by the Egyptian priest, Arbax, who has a grudge against Lysias, and is not what it seems, it is intended to drive whoever takes it insane. Hélène's new slave is also in love with Lysias. She steals the potion and gives it to Lysias, who hurries away in a mad rage. When the slave girl confronts Arbax, she is killed by the evil priest, and Lysias is charged with her murder.

Hardened criminal repeatedly breaks out of Oregon State Prison, eluding police for prolonged periods afterwards.

A beat patrolman doesn't believe that a neighborhood woman died of alcohol poisoning as the police detectives suspect. He continues his own investigation and, after discovering a drunk dead under similar suspicious circumstances, probes the connection between the two deaths.

The work of an observant bank president, a creative flight attendant and state of the art forensics for the time result in the quick apprehension of a bank robber.

Disguised a Western Union messenger, Willie Sutton (Jay Novello) tricks the janitor at a jewelry store on Broadway to open the door before the start of business. Sutton and an accomplice pull guns and prevent the janitor from warning the store manager when he arrives to open the store, and them force the manager to open the safe. The thieves make off with $130,000 in jewels, leaving a total of six hostages behind. Gang Buster detectives O'Reilly (Ray Walker) and Burlin (Eddie Marr) notice that a month earlier an attempted bank robbery began at the same time of day as the jewelry store job, using the same disguise and the same modus operandi. Employees of the bank identified pictures of Willie "The Actor" Sutton and escaped convict Marcus G. Bassett (Marc Krah) as leaders of the bank robbery gang. The Gang Busters know the name of Bassett's girlfriend and decide to try and get to Sutton through Bassett. While planning another bank robbery, Sutton sees Basset having an argument with his girlfriend Helen (Betty Lou Gerson), and wants to know what's wrong. When Bassett tells Sutton that he can't take her any more, Willie unsympathetically tells him that he better "look after" Helen instead of worrying about the bank job. Feeling threatened, Bassett recalls that Sutton had another partner in crime who was murdered over a girl, and does not want to end up lying in the street himself. Following the argument with Bassett, Helen turns out to be more than willing to give him up when the detectives arrive at her place, even telling them that both of the escapees carry poison vials so that they will never be taken alive and sent back to prison. The detectives miss Barrett but locate Sutton's naive girlfriend Violet Fairchild (Peggy Stewart) and follow her to a restaurant where she meets the unsuspecting Sutton. The Gang Busters surprise him, confiscate his poison, and haul him off to jail. Bassett is apprehended a few days later.

Detectives set out to track down a gang of international jewel thieves who have just stolen more than a million dollars worth of valuables from an estate in New York.

Charles Mendoro, an erstwhile family man, and his partner use poison gas to rob currency exchanges in Chicago.

Police pursue John Dillinger and his henchman, Homer Van Meter across the Midwest. On the run, Van Meter digs up loot hidden in glass jars, but is double-crossed by one of his underlings.

Police in Buffalo, NY, mount a search for a ring of deadly jewel thieves believed to be hiding across the border in Canada.

A policewoman goes undercover to infiltrate a gang of armed and dangerous criminals led by a vicious but beautiful blonde.

A masked phantom and his gang commit a series of payroll robberies, and the police can't seem to find a trace of them.

Federal agents set off on the trail of a family of bank robbers who have stolen more than $50,000 from an Oregon bank.

Three vicious hoods on a crime rampage take over a church mission as their headquarters, figuring the cops would never look for them there.

A Canadian-born cat burglar tries to maintain his blissful domestic life while stealing guests jewelry at parties on both coasts and selling them to unwitting gem merchants in other major cities. Police begin to close in when one of the merchants recognizes the man from a wanted poster he accidentally saw while applying for a gun license.

An ex-con just released from prison is reunited with his old criminal cronies with one change - his girl friend, a beautiful blonde with a sharp mind and a heart of stone, demands to call the shots for the gang. Things go well at for the crooks at first, until the woman decides she must have a beautiful, French-made red dress, but refuses to pay for it and a night watchman is slain during the botched robbery.

A criminal gang preying on bars and liquor stores in Manhattan and the Bronx has stayed one step ahead of the New York City Police Department. The first break the police get is when a patrolman stumbles across a pair of eyeglasses in the alley behind one of the robbery scenes. Using the frames, detectives create a composite sketch of one of the gang members and trace the owner due to the unusual lens prescription.

Federal Bureau of Investigation special agents are called in to capture the notorious bank robber and kidnapper Alvin Karpis, the machine gun blasting thug who provides the muscle for the infamous Karpis-Barker gang. Federal heat forces Karpis from hideout to hideout but Karpis always stays one step of the FBI. The G-men play their trump card and, knowing that the gangster loves fishing, manage to track their quarry to popular pier.

State police attempt to apprehend the brutal Scissors Gang, who have committed over 50 armed robberies across Connecticut.

John Dillinger, a notorious 1930s bank robber, escapes from the state penitentiary using a wooden gun, but makes a critical error when he crosses the state line in a stolen car. That act violated a U.S. law, causing the FBI to take up the hunt. Although Dillinger manages to escape from several traps set by the G-men, he's finally cornered by agents leaving a Chicago movie theater with "The Lady in Red".

Captain Stewart struggles with ideas to overcome the Barrow's gang use of state borders to avoid prosecution and thus bring Clyde Barrow, Bonnie Parker, and gang to justice.

Special Agents Sheldon and Randall of the F.B.I. pursue notorious jewel thief Arthur Bennett Burl. Burl funds his expensive life style by robbing the homes of wealthy acquaintances whom he meets socially through the beautiful women in his life who are unaware of the criminal activities and who unwittingly provide him alibis for his late-night burglar forays.

Al Rocco, a handsome, hot-headed hoodlum, is enraged when his wife decides to leave him because of his criminal activities. He plots to kill her with a camera-like apparatus that houses a deadly weapon and is instrument is a young woman who thinks she's taking a picture of a woman for a private detective.

Hardened criminal John Pinson escapes from the Oregon State Prison and goes on the run. While avoiding capture he murders a police officer.