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A man infected with a deadly virus boards Quantum Airlines flight 66 in Frankfurt, Germany. The US government must stop the plane before it lands at JFK International Airport.

Fuming over the departure of his wife Vivian and the cutting of his research funding, crazy nuclear scientist Rogers Henry constructs Medusa, a thermonuclear bomb capable of generating a continent-sized electro-magnetic pulse; such EMP could effectively destroy a computer-based society. He dupes Vivian into bringing it to the Pentagon to exact his final revenge on the government, rigging it so it will explode before its count-down if Vivian's pacemaker isn't within fifteen feet of it. Medusa arms itself in the air aboard Scott Nash's 737 cargo plane, and with Hurricane Sigrid about to hit the coast, nobody wants to let them land. Based on the novel by John J. Nance.