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"Me Estas Matando Susana" takes us on Eligio's quest to find and recover his wife, Susana, who without a word, left Mexico City behind for a writer's conference held in the chilly U.S. heartland.

Tired of being taken for granted by his wife and 3 daughters, Rodolfo Guerra wakes up one morning and decides not to go to work. Then the craziness begins.

Faced with the impending death of her beloved grandmother, Ema, a young woman dealing with an unwanted pregnancy, must resolve her relationship with her estranged, larger-than-life mother, and motherhood itself.

After being falsely accused of a murder, Marcos (Alcazar) runs away to the small and quiet town of Cuevano, where he has relatives. There he finds that the family matters are more complicated than his, and that the complexities of small-town life are richer (and more dangerous) than his apparently sophisticated life in the big city.