Ernesto Guevara de la Serna, popularly known as Che, along with his friend Alberto Granado, decides to take a road trip across South America. His experiences on the journey transform him.
The love lives of brothers Mickey and Francis interconnect as Francis cheats on his wife with Mickey's ex-girlfriend while Mickey impulsively marries a stranger.
A New York thief, a tough-as-nails hundred-year-old woman, two brothers from the Wild West, a Macedonian revolutionary and a beautiful pregnant woman, all cross paths in a tale that spans two continents and three centuries.
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