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Abby Arcane returns home to Marais, Louisiana to investigate a deadly swamp-borne virus, only to discover the dark, terrifying mysteries of the swamp.

CDC investigator Abby Arcane is sent to investigate a mysterious illness in Marais, where she and Matt encounter a creature born of the depths of the swamp's terrifying secrets.

Abby and Matt follow one of her patients into the swamp, where Abby encounters Swamp Thing; Alec struggles to understand his metamorphosis into the monstrous, plant-based creature, Swamp Thing.