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Eleven teams leave Santa Monica Pier and make their way to Montevideo, Uruguay, where they must locate a statue known as the "hand in the sand." In Uruguay, teams must carry a side of beef one-half mile, and then face the detour of "zips or chips" (zip lining from a hotel roof or playing roulette) before arriving at the pit stop.

The teams head to Montevideo in Uruguay, where they visit a foam discoteque and pop rubber balls to find clues. They all end up in the same ferry and feel the pressure of being bunched together after having been in various positions. They travel to Buenos Aires, where they take part in a Detour, Perro or Tango, in which you have to choose between walking eight dogs for about a mile, or instead first travel about a mile and a half for the Tango. In the Tango, the teams receive a photo and then try to identify one man from a group of people dancing the tango. The Tango turns out to be the better choice, because the dog-walking takes a long time and the dogs are difficult to control. After completing one of those two, the teams participate in a Roadblock in which they have to remove a scarf from a calf. Fortunes change for the teams, as many who were behind end up advancing, while Alison and Donny are eliminated.