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- A female jogger is found floating in the Schuylkill River. Dr. Megan Hunt teams up with her partner, medical investigator and former cop Peter Dunlop, under the watchful eye of their boss, Chief Medical Examiner Dr. Kate Murphy, who is very aware of Megan's gifted but polarizing work style. Megan's colleagues, Dr. Ethan Gross and Deputy Chief Medical Examiner Dr. Curtis Brumfield, must find their own way to work alongside the new medical examiner. Megan's investigation takes her out in the field where she meets old-school cop Detective Bud Morris, who is exasperated by Megan's tenacity and bull-headedness. But his partner, Detective Samantha Baker, possesses a quiet respect for Megan's input, even if Morris doesn't. Meanwhile, as she's is trying to solve the female jogger's death, Megan has to solve a personal puzzle of her own -- what is the perfect present for her daughter's 12th birthday?
- Megan goes to a scene wherein a couple were killed. She meets Detectives Morris and Baker who believe it's a murder suicide because the man has the gun in his hand. But Megan proves them wrong when she reveals that the man is left handed but the gun is in the right hand. Megan learns the girl comes from a wealthy family. She assures them she'll find out what happened to their daughter. She learns that they dated years ago but her parents didn't approve of her dating someone who is white. She learns she was involved with another guy who is controlling and domineering. She discovers that the guy went to see the boyfriend at his place of business to let her go. The boyfriend denies killing them and his alibi is his latest girl who is afraid of him. Megan tries to find out if he's making her lie. Baker and Morris learn that they crossed paths with a racist who didn't approve of him dating a black girl. Ethan discovers something about the guy which could led to another suspect. Megan tries to reconnect with her daughter but is so pushy that her daughter tells her so.
- A perfect neighborhood in the Philadelphia suburbs is shaken when a stay-at-home dad is found stabbed to death in his home. As Megan unravels the mystery of his death and who killed him, she recalls how she learned of her own father's death. Meanwhile, Peter helps Megan juggle her biggest challenge yet, taking charge of the Saturday carpool with her hard-to-impress daughter, Lacey, and her girlfriends. Also, Kate takes on a consulting role in a pro bono case with Megan's ex-husband, Todd.
- Megan re-enters the high society world to which she once belonged when a top magazine editor is found dead at her Chestnut Hill mansion. Megan accepts her mother's invitation to a social event with the ulterior motive of confronting a prime suspect, appalling her mother in the process. When Kate asks Ethan to investigate the only trace evidence found at the murder scene, he's surprised by her uncharacteristically upbeat and supportive attitude.
- When a body that was buried starts sticking up, Megan goes and she learns the body was dismembered and not all of the parts are there. They somehow learn who the person is and go to this apartment and it's there that they find the rest of him, in the freezer. They learn she has a daughter who's married to an apathetic man who's irate that her father came to them for money. They also learn that his neighbors don't like him, too. They learn he went to a casino and won some money but it's not at his place so did the killer take it. And Lacey wants to go to Megan's place of work and record her and her co-workers. When she goes Megan establishes some ground rules but Lacey feels like she's tying her hands and not showing her anything meaty.
- During the autopsy of a young woman murdered in a seedy hotel room, Megan is shocked to discover her own special connection to the victim. Meanwhile, after learning to her surprise of some personal challenges her colleagues are dealing with, Megan realizes how much goes on around her that she's been missing, and takes a sudden interest, much to her colleagues' amusement.
- Karen Archer is the identical twin of a beautiful corpse, Jessica, whose mysterious death keeps Ethan and Curtis guessing. As Ethan's personal interest in this case deepens, Curtis begins questioning Ethan's motives. Meanwhile, Megan faces old demons when she visits her former boss at the hospital where she used to practice. A patient has died after recent surgery. Was it murder or malpractice? Megan begins to suspect the victim's doctor, but as soon as she starts ruffling feathers, the hospital stonewalls.
- Megan investigates the death of a young nanny run down by a car and discovers that her 5-year-old charge has been kidnapped -- and requires medication. A handsome FBI agent, Derek Ames, is assigned to the case. Meanwhile, Bud comes under scrutiny when an interrogation of the prime suspect in the kidnapping takes a wrong turn; and Megan's mother, Joan, offers to help her, but Megan is leery - is it just a PR stunt for her mother's re-election?
- Peter stumbles upon a house fire in progress before the fire department arrives and is able to rescue a young woman. When Megan goes to the scene of the fire, she discovers that there is another victim who perished in the fire. This dismays Peter, who didn't know there was someone else in the house and now has a personal attachment to this case. As Megan begins her investigation, she is usurped by veteran arson investigator Ray Easton and his young colleague, Skip, who challenge her at every step. When Megan complains to her boss, Kate wryly remarks that people usually find Megan impossible to work with, and the tension between the two women heats up more.
- When a popular 17-year-old high school student is found dead after a rave, the team must decipher various unknown drugs in his system and multiple bruises to figure out the cause of death. Meanwhile, Meghan is finally starting to date again after the divorce, but her ex-husband springs some shocking news on her and her daughter, causing tension at home.
