Zach Roerig, Michael Trevino and Paul Wesley originally auditioned to play Damon before landing their respective roles.
All episodes in season 8 are titled after quotes in the first season.
The casting for Klaus took so long that the character's introduction to the show had to be delayed. To replace Klaus in the episodes he was first meant to appear in, the character of Elijah was created. (Elijah is a creation of the show. Klaus is the only member of the Mikaelson family to have originated in the source books by L.J. Smith.)
Nina Dobrev was born in Bulgaria and speaks Bulgarian. For this reason Katherine, who was German in the books, became Bulgarian in the series.
According to Julie Plec The Vampire Diaries' end date depends on Paul Wesley and Ian Somerhalder
Julie Plec: "I finally realized that my destiny on this show, creatively, is tied in to Ian Somerhalder and Paul Wesley. And I mean that in a really good way. As long as those boys who I now consider my friends want to keep telling the story, then I won't walk away from telling the story."