late 14c., agonie, "mental suffering" (especially that of Christ in the Garden of Gethsemane), from Old French agonie, agoine "anguish, terror, death agony" (14c.), and directly from Late Latin agonia, from Greek agōnia "a struggle for victory" (in wrestling, etc.), in a general sense "exercise, gymnastics;" also of mental struggles, "agony, anguish."

This is from agōn "assembly, mass of people brought together," especially to watch the games, hence, "a contest," then, generally, "any struggle or trial;" from the verb agein "put in motion, move" (here specifically as "assemble, bring together"), which is reconstructed to be from PIE root *ag- "to drive, draw out or forth, move."

In English, specifically of the struggle that precedes natural death (mortal agony) from 1540s. The sense development perhaps involves "pain so severe as to cause struggling." The sense of "extreme bodily suffering" is recorded by c. 1600.

I like a look of Agony,

Because I know it's true

[Emily Dickinson]

"one who contends with another," 1590s, from French antagoniste (16c.) or directly from Late Latin antagonista, from Greek antagonistēs "competitor, opponent, rival," agent noun from antagonizesthai "to struggle against, oppose, be a rival," from anti "against" (see anti-) + agonizesthai "to contend for a prize," from agon "a struggle, a contest" (see agony). Originally in battle or sport, extended 1620s to any sphere of human activity.

Proto-Indo-European root forming prepositions, etc., meaning "forward," and, by extension, "in front of, before, first, chief, toward, near, against," etc.

It might form all or part of: afford; approach; appropriate; approve; approximate; barbican; before; deprive; expropriate; far; first; for; for-; fore; fore-; forefather; foremost; former (adj.); forth; frame; frau; fret; Freya; fro; froward; from; furnish; furniture; further; galore; hysteron-proteron; impervious; improbity; impromptu; improve; palfrey; par (prep.); para- (1) "alongside, beyond; altered; contrary; irregular, abnormal;" paradise; pardon; paramount; paramour; parvenu; pellucid; per; per-; percent; percussion; perennial; perestroika; perfect; perfidy; perform; perfume; perfunctory; perhaps; peri-; perish; perjury; permanent; permeate; permit; pernicious; perpendicular; perpetual; perplex; persecute; persevere; perspective; perspire; persuasion; pertain; peruse; pervade; pervert; pierce; portray; postprandial; prae-; Prakrit; pre-; premier; presbyter; Presbyterian; preterite; pride; priest; primal; primary; primate; primavera; prime; primeval; primitive; primo; primogenitor; primogeniture; primordial; primus; prince; principal; principle; prior; pristine; private; privilege; privy; pro (n.2) "a consideration or argument in favor;" pro-; probably; probe; probity; problem; proceed; proclaim; prodigal; produce; profane; profess; profile; profit; profound; profuse; project; promise; prompt; prone; proof; proper; property; propinquity; prophet; prose; prostate; prosthesis; protagonist; Protean; protect; protein; Proterozoic; protest; proto-; protocol; proton; protoplasm; Protozoa; proud; prove; proverb; provide; provoke; prow; prowess; proximate; Purana; purchase; purdah; reciprocal; rapprochement; reproach; reprove; veneer.

It might also be the source of: Sanskrit pari "around, about, through," parah "farther, remote, ulterior," pura "formerly, before," pra- "before, forward, forth;" Avestan pairi- "around," paro "before;" Hittite para "outside of," Greek peri "around, about, near, beyond," pera "across, beyond," paros "before," para "from beside, beyond," pro "before;" Latin pro "before, for, on behalf of, instead of," porro "forward," prae "before," per "through;" Old Church Slavonic pra-dedu "great-grandfather;" Russian pere- "through;" Lithuanian per "through;" Old Irish ire "farther," roar "enough;" Gothic faura "before," Old English fore (prep.) "before, in front of," (adv.) "before, previously," fram "forward, from," feor "to a great distance, long ago;" German vor "before, in front of;" Old Irish air- Gothic fair-, German ver-, Old English fer-, intensive prefixes.

Proto-Indo-European root meaning "to drive, draw out or forth, move."

It might form all or part of: act; action; active; actor; actual; actuary; actuate; agency; agenda; agent; agile; agitation; agony; ambagious; ambassador; ambiguous; anagogical; antagonize; apagoge; assay; Auriga; auto-da-fe; axiom; cache; castigate; coagulate; cogent; cogitation; counteract; demagogue; embassy; epact; essay; exact; exacta; examine; exigency; exiguous; fumigation; glucagon; hypnagogic; interact; intransigent; isagoge; litigate; litigation; mitigate; mystagogue; navigate; objurgate; pedagogue; plutogogue; prodigal; protagonist; purge; react; redact; retroactive; squat; strategy; synagogue; transact; transaction; variegate.

It might also be the source of: Greek agein "to lead, guide, drive, carry off," agon "assembly, contest in the games," agōgos "leader," axios "worth, worthy, weighing as much;" Sanskrit ajati "drives," ajirah "moving, active;" Latin actus "a doing; a driving, impulse, a setting in motion; a part in a play;" agere "to set in motion, drive, drive forward," hence "to do, perform," agilis "nimble, quick;" Old Norse aka "to drive;" Middle Irish ag "battle."