Dr. Keith Baar is a professor at the University of California, Davis, in the Department of Physiology and Membrane Biology.
During his PhD studies, his research revealed that mechanical strain on muscle fibers activates the mammalian target of rapamycin (mTOR) signaling pathway, a crucial regulator of muscular hypertrophy.
Subsequently, he studied the molecular dynamics of skeletal muscle adaptation to endurance training under the guidance of Dr. John Holloszy, a legend in the field of exercise physiology, considered the father of modern exercise biochemistry.
Building on all of this experience, he conducted research into tendon health and the potential for engineering ligaments, which could have implications for treatment and recovery from injuries.
Dr. Baar now runs the Functional Molecular Biology Lab at UC Davis. His lab’s work ranges from studying molecular changes in our cells to conducting studies to effect real-world improvements in people’s health, longevity, and quality of life.
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Want to hear another episode that explores the possibilities of rapamycin? Have a listen to the conversation I had with Peter Attia, David M. Sabatini, and Navdeep S. Chandel at the source of this miraculous compound: Easter Island. Here, we discuss how one of the most important discoveries of medical science was almost lost, why metabolism (along with longevity) research is key to treating a long list of diseases, intermittent dosing of rapamycin, parenting advice from scientists on confidence and conflict, the necessary failures of good science, good fonts versus bad fonts, “non-potato” relationships, and much more.
What was your favorite quote or lesson from this episode? Please let me know in the comments.
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