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- Saint
- Sakura Wars V
- Sam and Max Beyond Time and Space (Season 2)
- Sam and Max Save the World (Season 1)
- Secret Files 2: Puritas Cordis
- Secret Files: Tunguska
- Sherlock Holmes: Secret of the Silver Earring
- Shikigami no Shiro III
- Silent Hill: Shattered Memories
- Sin and Punishment: Star Successor
- Sonic the Hedgehog 4
- Spy Fox in Dry Cereal
- Stonekeep: Bones of the Ancestors
- Strong Bad’s Cool Game for Attractive People
